Buy FOXO4-DRI Peptide in Australia

Buy FOXO4-DRI in Australia from Macropus Peptides in a sealed 10mg vial for cellular senescence research. It is a synthetic D-retro-inverso peptide that mimics the region of the FOXO4 transcription factor which binds p53, and it was designed to disrupt that interaction in senescent cells. Built from D-amino acids, it resists protease breakdown in culture, and an arginine-rich segment lets cells take it up. Each vial holds freeze-dried research material labelled with compound, fill, lot number and storage temperature, and a certificate of analysis is available for every lot. The 10mg vial is quoted on request, so we confirm the price before you commit, and one vial covers a full cell culture series with senescent and control arms. Order FOXO4-DRI online with bacteriostatic water, and your parcel is dispatched from Australian stock to any Australian address. Sold to adults for in-vitro laboratory research only, never for human or veterinary use.

Compound	FOXO4-DRI
Amount	10 mg
Form	Lyophilised powder
Category	Longevity and cognitive
Storage	-20 °C, protect from light
Testing	HPLC purity and mass spectrometry identity, every batch
Certificate of analysis	Available for every lot, matched to the lot number on the label

FOXO4-DRI 10mg vial

Enter the diluent volume added to this vial to see the solution concentration. Laboratory calculation only, not dosing guidance.

Diluent added (mL)

Buy FOXO4-DRI Australia: 10mg Research Peptide Vial

Macropus Peptides lists this peptide in a single 10mg vial for laboratories working on cellular senescence. The vial is quoted on request: ask us and we confirm a price before anything is charged. Most compounds studied for clearing senescent cells are small molecules borrowed from cancer or nutrition research, whereas this one was designed around a single protein interaction that becomes important once cells turn senescent.

What is FOXO4-DRI peptide

FOXO4 is a transcription factor from the Forkhead box O family. FOXO4-DRI is a synthetic peptide that mimics the part of FOXO4 which binds p53, the tumour suppressor protein. DRI stands for D-retro-inverso: the sequence is built from D-amino acids and assembled in reverse order, so the side chains sit in roughly the same positions as in the natural peptide while the backbone is no longer recognised by most protein-digesting enzymes. The construct also carries an arginine-rich cell-penetrating segment, which lets cultured cells take it up. It was first described in Cell in 2017.

How FOXO4-DRI works in research

Senescent cells stop dividing but resist dying, and they release inflammatory signals that affect the tissue around them. In these cells FOXO4 levels rise and the protein holds p53 inside the nucleus, where p53 keeps the cell in arrest instead of triggering programmed cell death. The peptide competes for that interaction. Once released, p53 leaves the nucleus and the senescent cell can enter apoptosis through the mitochondrial pathway. Dividing cells rely far less on the FOXO4 and p53 pairing, which is why the original work compared senescent and normal fibroblasts in culture to test selectivity. Laboratories use it to study senescence, the FOXO4 and p53 axis and senolytic selectivity, usually beside a small-molecule comparator.

FOXO4-DRI research: what the studies show

The founding paper, published in Cell in 2017, combined cell culture with mouse models of chemotherapy-induced damage and natural ageing, and studied the FOXO4 and p53 interaction and the clearance of senescent cells. A 2018 review in FEBS Letters placed the FOXO4 and p53 axis within the wider regulation of senescence, and a 2017 review in Nature Reviews Drug Discovery surveyed senescent cell biology and the approaches used to target it. Later groups have applied the peptide to other senescent cell models, but the record remains small. See our FOXO4-DRI research studies library for designs and measurements.

FOXO4-DRI vial specifications

A single sealed vial holds 10mg of the peptide as a freeze-dried solid. Its wraparound label gives the name, fill, batch code and a freezer storage temperature, and the batch code lets us send the matching certificate of analysis. The D-amino acid backbone resists proteases but not heat, moisture or light, so store it in a dark freezer near -20 °C and let it warm to room temperature before the seal is broken. Once mixed, the solution lives in the refrigerator and is not returned to a freezer.

FOXO4-DRI price in Australia

The 10mg vial does not yet carry a list price and is quoted on request. An enquiry brings back a firm quotation that you accept before anything is placed; a tenth of that quotation is the cost per milligram of peptide.

FOXO4-DRI 10mg: where to buy in Australia

The 10mg fill is our only size, enough for a complete cell culture series on one lot, including senescent and non-senescent controls. Reconstituted at 2 mL the peptide stands at 5 mg per mL; at 1 mL it stands at 10 mg per mL. Because the cationic cell-penetrating segment can stick to plastics at low working concentrations, prepare final dilutions in low-retention tubes.

Best place to buy FOXO4-DRI Australia

• A single 10mg vial quoted before you commit to buy
• Printed batch code linked to its own certificate
• Held locally, so nothing is imported per order
• Epitalon, SS-31 and NAD+ available for comparison work
• Plain research-only terms with no claims about use in people

How to buy FOXO4-DRI online

• Send a quote request for the 10mg vial
• Once the price is confirmed, add the quantity you need
• Include a diluent if your laboratory does not hold one
• At checkout, confirm adult age and a senescence research purpose
• Log the batch code and request its certificate on arrival

FOXO4-DRI calculator: mixing the 10mg vial with bac water

Work out the stock by dividing ten milligrams by the millilitres you add: made up to 1 mL the peptide is at 10 mg per mL, to 2 mL at 5, to 4 mL at 2.5 and to 5 mL at 2. One bacteriostatic water 10mL vial stretches across several reconstitutions; other diluents are in our research supplies.

Is FOXO4-DRI available in Australia

Yes, as a research tool compound only. There is no ARTG entry and no TGA approval for this peptide, and we release it for laboratory work alone, excluding any human or veterinary use. The TGA sets Poisons Standard scheduling, and entries can change, so institutional buyers should confirm the current position at the time of ordering.

FOXO4-DRI for sale Australia wide

Senescence and ageing research groups in every state, including Melbourne, Perth, Newcastle and Rockhampton, receive their vials by tracked post. For comparison work, researchers add Epitalon, a telomerase-focused bioregulator, SS-31 for mitochondrial readouts, or NAD+ for coenzyme studies. Our longevity and cognitive range lists the rest.

Questions about FOXO4-DRI 10mg