Buy 5-Amino-1MQ in Australia
Buy 5-Amino-1MQ in Australia from Macropus Peptides as a 50mg research vial, priced and ready to order, with a 5mg vial quoted on request. 5-Amino-1MQ, or 5-amino-1-methylquinolinium, is a small molecule rather than a peptide: a membrane-permeable inhibitor of nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide using S-adenosylmethionine. Blocking that enzyme lets laboratories study how it shapes NAD+ salvage and methyl donor supply in fat and liver cell models. Each vial holds the compound as a dry solid, labelled with name, strength, lot number and storage temperature, with a certificate of analysis for every lot. The 50mg vial gives the lower cost per milligram and keeps long assay series on one lot. Order online and your parcel ships from our Australian shelves to any address in the country. 5-Amino-1MQ is sold to adults aged 18 and over for in-vitro laboratory research only, not for human or veterinary use.
| Compound | 5-Amino-1MQ |
|---|---|
| Amount | 50 mg |
| Form | Lyophilised powder |
| Category | Metabolic research |
| Storage | -20 °C, protect from light |
| Testing | HPLC purity and mass spectrometry identity, every batch |
| Certificate of analysis | Available for every lot, matched to the lot number on the label |
5-Amino-1MQ 50mg vial
Enter the diluent volume added to this vial to see the solution concentration. Laboratory calculation only, not dosing guidance.
Buy 5-Amino-1MQ Australia: 5mg and 50mg Vials
Macropus Peptides supplies this NNMT inhibitor in two sizes: a 50mg vial with a listed price and a 5mg vial by quote. A quinolinium compound rather than a peptide, it is listed with our metabolic compounds because it is routinely run next to metabolic peptides, and both sizes come from one lot-released supply.
5-Amino-1MQ Australia: what is 5-Amino-1MQ
The compound is 5-amino-1-methylquinolinium, a quinoline ring carrying a methyl group on its nitrogen and an amino group at position five. That methylated nitrogen gives it a permanent positive charge, yet cell-based assays characterised it as able to cross membranes. It came out of structure-activity work on quinolinium analogues designed to sit in the nicotinamide binding pocket of nicotinamide N-methyltransferase, usually shortened to NNMT, and it was one of the more potent and selective members of that series.
5-Amino-1MQ NNMT inhibitor: the enzyme it blocks
NNMT moves a methyl group from S-adenosylmethionine, the cell's main methyl donor, onto nicotinamide. The products are 1-methylnicotinamide and S-adenosylhomocysteine. The enzyme therefore sits where two pathways meet: it uses up methyl donor capacity, and it takes nicotinamide away from the salvage route that rebuilds NAD+. It is highly expressed in adipose tissue and liver. By inhibiting it, researchers can test how that junction influences cellular NAD+ levels, S-adenosylmethionine availability and downstream methylation in adipocyte and hepatocyte cultures, and compare the effect with supplying the cofactor directly through NAD+.
5-Amino-1MQ research: what the published studies show
Interest in the enzyme as a metabolic target grew from a 2014 Nature paper in which antisense knockdown of NNMT in mouse adipose tissue and liver was used to study energy expenditure and NAD+ and methyl donor metabolism. The quinolinium series was then mapped in a 2017 structure-activity paper, in the Journal of Medicinal Chemistry, that measured enzyme inhibition across analogues. A 2018 study in Biochemical Pharmacology examined selectivity, cell permeability and effects in adipocytes and a high-fat diet mouse model. All three appear in our 5-Amino-1MQ research studies library.
5-Amino-1MQ vial specifications
| Specification | Detail |
|---|---|
| Compound | 5-Amino-1MQ |
| Amount | 50 mg |
| Form | Lyophilised powder |
| Category | Metabolic research |
| Storage | -20 °C, protect from light |
Rather than a peptide cake, the vial holds a dry crystalline solid under a crimped cap. The label shows compound, milligram content, lot and storage temperature, and the matching certificate follows when you send that lot. Keep it at -20 °C away from light, and let it reach room temperature before opening so condensation does not settle on the solid.
5-Amino-1MQ price in Australia
| Strength | Price | Price per mg |
|---|---|---|
| 5-Amino-1MQ 5mg | Price to confirm | - |
| 5-Amino-1MQ 50mg | $119.99 | $2.40 per mg |
The 50mg quinolinium vial carries a published price and leaves from stock, whereas the 5mg vial is quoted. With ten times the material, the larger vial is very likely to remain the cheaper option per milligram, so the small size makes sense only where a study truly needs a small quantity.
5-Amino-1MQ 50mg: where to buy in Australia
Most laboratories order the 50mg vial. It is priced, orderable today and holds enough for repeated enzyme assays and multi-plate cell work on one lot. As a small, stable solid it keeps well between experiments when stored dry and cold. Stock strengths for this size:
- 5 mL: 10 mg per mL
- 10 mL: 5 mg per mL
5-Amino-1MQ 5mg: small vial, price on request
The 5mg vial fits a single inhibition curve, a solubility check or a short culture experiment. Ask us for a quote. One millilitre of solvent brings the small 5-Amino-1MQ vial to 5 mg per mL; using 0.5 mL instead doubles it, equal to the 50mg vial in five millilitres.
Best place to buy 5-Amino-1MQ Australia
- A priced 50mg vial for full studies and a 5mg vial on quote
- Both sizes drawn from a single lot-released source
- Lot code on the label and a batch certificate
- Sent from inside Australia with no international customs step
- Related metabolic tools, kits and diluents in one order
5-Amino-1MQ how to get: buy 5-Amino-1MQ online
- Put the 50mg vial in the cart, or ask us to quote 5mg
- Choose the quantity your study needs
- Order the solvent or diluent your method names
- Pay after declaring adult age and a research purpose
- Save the lot code and request its certificate
5-Amino-1MQ calculator: solvent volumes for 5mg and 50mg
Key a solvent volume into the listing's quinolinium calculator to read off the stock concentration in milligram and microgram terms. For the 50mg vial:
- 5 mL: 10 mg per mL
- 10 mL: 5 mg per mL
For the 5mg vial:
- 1 mL: 5 mg per mL
Where an aqueous stock suits your protocol, bacteriostatic water can join the order, and other diluents are in lab supplies. The 5-Amino-1MQ starter kit bundles the 50mg vial, 3 mL of bacteriostatic water, syringes and swabs.
Is 5-Amino-1MQ available in Australia
Yes, as a research chemical only. The quinolinium compound is absent from the ARTG and lacks TGA approval; it is never sold for human or animal use, only for in-vitro chemistry and cell work. Chemicals of this kind are scheduled through the Poisons Standard, which is revised periodically, so check today's listing for your organisation.
5-Amino-1MQ for sale Australia wide
Parcels go from Australia to laboratories in every capital and regional university town, with vials packed upright. It is often ordered with SLU-PP-332, another non-peptide metabolic tool, and with MOTS-C; all three come together in the metabolic trio. See the full metabolic research range.
References
- Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014.
- Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. Journal of Medicinal Chemistry. 2017.
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018.
Scientific content compiled from the peer-reviewed literature above by the Macropus Peptides technical team. Information is provided for research reference only.